Authors: Hyung Hwa Jeong, MD; Joon Pio Hong, MD, PhD; et al.
Affiliation: Asan Medical Center, University of Ulsan College of Medicine
Journal: The International Journal of Lower Extremity Wounds (2023)

This preclinical study evaluated the efficacy of topical escin gel (Resilio D) in an acute lymphedema rat tail model. Among the four concentrations tested (0.5%, 2%, 10%, 20%), the 2% escin group demonstrated the most significant improvements in:

• Tail volume reduction (26.8%)

• Dermal thickness decrease (p=0.034)

• Lymphatic vessel regeneration (LYVE-1 expression, p<0.05)

The authors conclude that 2% escin may be the optimal concentration for improving acute lymphedema.

This study supports the potential of Resilio D as a non-invasive topical treatment for lymphedema.